With a highly practical approach, this guide focuses on mainstreaming the gender and disability perspectives within European Social Fund (ESF) programmes. The ESF is the main European funding mechanism for overcoming social inequalities, with a particular attention to employment and training. Based on several actions co-funded by the ESF and delivered by Fundación ONCE through its entity Inserta Empleo, this guide provides insight and recommendations for truly inclusive and equal actions in the field of labour market inclusion for people with disabilities. This is an innovative guide which is co-funded by the ESF, published in partnership with the CERMI Women’s Foundation, and applies the invaluable viewpoint of ‘intersectionality’. It has been developed in the framework of Disability Hub Europe, led by Fundación ONCE with the co-funding of the ESF and reflects a contribution to the 2030 Agenda and the Sustainable Development Goals, particularly SDG 8 related to employment and SDG 5 related to gender equality.