This document summarizes the results achieved by Caritas Spain, the Spanish Red Cross, Fundación ONCE and Fundación Secretariado Gitano within the European Social Fund Operational Programme “Fight against Discrimination” between the years 2000 and 2015. During this period, these four organizations have assisted 850,000 people in vulnerable and exclusion situations and have contributed to provide employment for 230,000. Moreover, these entities have promoted more than 1,000 entrepreneurship and self-employment initiatives.